Kluger Benzi M, Pedersen Kenn Freddy, Tysnes Ole-Bjorn, Ongre Solgunn O, Øygarden Bjørg, Herlofson Karen
Department of Neurology, University of Colorado Anschutz Medical Campus, 12631 E 17thAvenue, Aurora, CO 80045, USA.
Department of Neurology, The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Gerd-Ragna Bloch Thorsens gate 8, 4011 Stavanger, Norway.
Parkinsonism Relat Disord. 2017 Apr;37:87-91. doi: 10.1016/j.parkreldis.2017.02.005. Epub 2017 Feb 7.
Fatigue is a common and disabling symptom which may be seen in early Parkinson's disease (PD). Our understanding of the phenomenology and etiology of fatigue in PD is limited. The objective of this study was to determine whether fatigue was related to cognition in early PD patients.
The study is part of the Norwegian ParkWest project, a population-based cohort study, comprising 184 de novo, drug-naïve patients with PD. PD was diagnosed according to the Gelb criteria. Fatigue was assessed by the Fatigue Severity Scale (FSS). Cognition was assessed by a battery of tests evaluating functions in the domains of verbal memory, processing speed, executive function and visuospatial abilities.
107 of the cohort had moderate to severe fatigue (FSS ≥ 4). In univariate correlation analyses high fatigue score was correlated to disease severity, presence of sleep problems, depressive symptoms, apathy, reduced processing speed and reduced visuospatial abilities. In a multiple regression analysis only disease severity (measured by the UPDRS part 3), sleep problems, depressive symptoms and reduced visuospatial abilities contributed to the model.
Fatigue is associated with visuospatial function in early PD patients. Further studies are needed to determine the pathophysiologic relevance of this association.
疲劳是一种常见且使人衰弱的症状，在早期帕金森病（PD）中可能会出现。我们对PD中疲劳的现象学和病因学的理解有限。本研究的目的是确定疲劳是否与早期PD患者的认知有关。
该研究是挪威ParkWest项目的一部分，这是一项基于人群的队列研究，包括184例初发、未用药的PD患者。PD根据Gelb标准进行诊断。疲劳通过疲劳严重程度量表（FSS）进行评估。认知通过一系列测试进行评估，这些测试评估言语记忆、处理速度、执行功能和视觉空间能力等领域的功能。
该队列中有107例有中度至重度疲劳（FSS≥4）。在单变量相关分析中，高疲劳评分与疾病严重程度、睡眠问题、抑郁症状、冷漠、处理速度降低和视觉空间能力降低相关。在多元回归分析中，只有疾病严重程度（由UPDRS第3部分测量）、睡眠问题、抑郁症状和视觉空间能力降低对模型有贡献。
疲劳与早期PD患者的视觉空间功能有关。需要进一步研究来确定这种关联的病理生理学相关性。
