Fois A, Malandrini F, Mostardini R
Brain Dev. 1987;9(2):82-4. doi: 10.1016/s0387-7604(87)80022-0.
The results of corticotropin treatment of 33 subjects with infantile spasms are reported. In 8 patients the disease was idiopathic and in 25 secondary. Among the idiopathic cases, full clinical and EEG normalization was obtained in 5. No anticonvulsants were given after the corticotropin treatment. All children have remained normal without therapy. Among the 25 secondary cases, complete normalization was obtained in one with meningioma and improvement in 15 others. The dosage of ACTH was usually 2 U/Kg/bw for 10 days and 10 U/Kg/bw on alternate days for a further 20 days. These findings indicate that therapeutic results quite similar to the most favourable reported in the literature can be obtained, with few side effects, with a low dosage and a short period of treatment with corticotropin.
报告了对33例婴儿痉挛症患者进行促肾上腺皮质激素治疗的结果。8例患者的疾病为特发性，25例为继发性。在特发性病例中，5例实现了全面的临床和脑电图正常化。促肾上腺皮质激素治疗后未给予抗惊厥药物。所有儿童未经治疗均保持正常。在25例继发性病例中，1例患有脑膜瘤的患者实现了完全正常化，其他15例有所改善。促肾上腺皮质激素的剂量通常为2 U/Kg/体重，持续10天，之后每隔一天10 U/Kg/体重，再持续20天。这些结果表明，使用低剂量促肾上腺皮质激素进行短期治疗，副作用少，可获得与文献中报道的最理想结果相当类似的治疗效果。
