Daghero A M, Bradley E L, Kissin I
Anesth Analg. 1987 Oct;66(10):944-7.
The effect of midazolam on morphine analgesia was studied in 54 rats. Analgesia was determined by measuring threshold for motor response to noxious pressure applied to the tail. Midazolam (0.5 mg/kg) decreased the morphine-induced (1 mg/kg) increase in the reaction threshold by one-half. Flumazepil (Ro 15-1788), a specific antagonist of benzodiazepines, prevented inhibition of morphine antinociception by midazolam. These findings demonstrate that midazolam partially antagonizes the analgesic effect of morphine and, in addition, that the antagonism of midazolam on morphine analgesia is mediated by benzodiazepine receptors.
在54只大鼠中研究了咪达唑仑对吗啡镇痛作用的影响。通过测量对施加于尾巴的有害压力的运动反应阈值来确定镇痛效果。咪达唑仑（0.5毫克/千克）使吗啡诱导（1毫克/千克）的反应阈值升高减半。氟马西尼（Ro 15-1788），一种苯二氮䓬类的特异性拮抗剂，可防止咪达唑仑对吗啡抗伤害感受的抑制作用。这些发现表明，咪达唑仑部分拮抗吗啡的镇痛作用，此外，咪达唑仑对吗啡镇痛的拮抗作用是由苯二氮䓬受体介导的。
