Rosanda C, Garaventa A, Pasino M, Strigini P, De Bernardi B
Anticancer Res. 1987 May-Jun;7(3 Pt B):365-7.
A short-term in vitro chemosensitivity test has been applied to 131 specimens from 109 children with various malignancies. The clinical outcome was correlated with in vitro percentage inhibition (PI) of DNA synthesis by the drug tested. In 62 correlations, PIs of responsive and of resistant patients differed significantly, with a cut-off value of 37%. The test predicted clinical resistance in 53/54 cases, with a specificity of 98%, and clinical response in 8/8 cases, with a sensitivity of 100%. This test can be useful particularly in predicting chemoresistance in relapsing patients, to avoid unnecessary toxicity.
一项短期体外化学敏感性试验已应用于109名患有各种恶性肿瘤的儿童的131份标本。临床结果与受试药物对DNA合成的体外抑制率（PI）相关。在62组相关性分析中，反应性和耐药性患者的PI有显著差异，临界值为37%。该试验在54例中有53例预测了临床耐药性，特异性为98%，在8例中有8例预测了临床反应性，敏感性为100%。该试验尤其有助于预测复发患者的化疗耐药性，以避免不必要的毒性。
