Komuro Y, Ohnishi M, Saitoh A, Morohashi Y
Gan To Kagaku Ryoho. 1987 Sep;14(9):2688-91.
Fourty-four patients with advanced non-small cell cancer of the lung were treated with a combination chemotherapy of mitomycin C, endoxan, and cisplatin (MEP). The overall response rate was 20%, with 9 partial responses. The median duration of response was 7 months. The overall median survival was 10 months. No significant difference was noted in survival time between PR and NC. MEP therapy seems to provide a relatively easy therapeutic approach in the treatment of advanced lung cancer with no associated renal toxicity or loss of hair.
44例晚期非小细胞肺癌患者接受了丝裂霉素C、环磷酰胺和顺铂联合化疗(MEP)。总缓解率为20%,有9例部分缓解。缓解的中位持续时间为7个月。总中位生存期为10个月。PR和NC之间的生存时间无显著差异。MEP疗法似乎为晚期肺癌的治疗提供了一种相对简便的治疗方法,且无相关肾毒性或脱发问题。