早期胃癌预后在性别和年龄方面的差异。
Differences in the prognosis of early gastric cancer according to sex and age.
作者信息
Suh Do Dam, Oh Seong Tae, Yook Jeong Hwan, Kim Byung-Sik, Kim Beom Su
机构信息
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-Gu, Seoul 05505, Korea.
出版信息
Therap Adv Gastroenterol. 2017 Feb;10(2):219-229. doi: 10.1177/1756283X16681709. Epub 2016 Dec 13.
BACKGROUND
Few studies have compared early gastric cancer (EGC) outcomes according to sex and age.
METHODS
We retrospectively reviewed 2085 patients who underwent curative gastrectomy for EGC between 1989 and 2000. Prognosis and risk factors for nodal involvement were evaluated according to sex and age.
RESULTS
Male sex and age were independent prognostic factors for overall survival (OS) but not relapse-free survival (RFS). In young (⩽55 years) patients, there were no significant differences in RFS and OS between men and women. However, older (>55 years) men had a poorer OS and older women had a poorer RFS. Young female patients had a higher proportion of gastric cancer-related death than young male patients. Female sex was an independent risk factor for nodal involvement in younger patients.
CONCLUSIONS
Young women with EGC should be more intensively treated and monitored than other patient groups and should not be treated by endoscopic resection.
背景
很少有研究根据性别和年龄比较早期胃癌（EGC）的治疗结果。
方法
我们回顾性分析了1989年至2000年间接受EGC根治性胃切除术的2085例患者。根据性别和年龄评估了淋巴结转移的预后和危险因素。
结果
男性和年龄是总生存期（OS）的独立预后因素，但不是无复发生存期（RFS）的独立预后因素。在年轻（≤55岁）患者中，男性和女性的RFS和OS无显著差异。然而，老年（>55岁）男性的OS较差，老年女性的RFS较差。年轻女性患者与胃癌相关的死亡比例高于年轻男性患者。女性是年轻患者淋巴结转移的独立危险因素。
结论
与其他患者群体相比，年轻的EGC女性患者应接受更积极的治疗和监测，不应采用内镜切除术治疗。
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