Guner Gunes, Kurtulan Olcay, Kav Taylan, Sokmensuer Cenk, Gedikoglu Gokhan, Akyol Aytekin
Department of Pathology, Faculty of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey.
Gastroenterology Division, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey.
Case Rep Pathol. 2017;2017:2753487. doi: 10.1155/2017/2753487. Epub 2017 Jan 19.
Granulomas are rarely seen in gastric biopsies mostly as an involvement of granulomatous diseases like sarcoidosis, Crohn's disease, infections, neoplasms, and vasculitis. Here, we claim cyanoacrylate as a foreign body type granuloma-causing agent in the stomach after vascular embolisation. We present cyanoacrylate associated gastric changes of three cases: two endoscopic biopsies and one gastric resection. In two cases, cyanoacrylate associated ulcers and granulomatous inflammation were observed in gastric mucosal biopsies following endoscopic examination after 7 months and 6 years of the glue injections, respectively. In the third case, the cyanoacrylate injection was performed 2 months prior to the surgery. Then the patient underwent distal pancreatectomy for pancreatic adenocarcinoma and during the operation a gastric mass was resected with a suspicion of tumoral infiltration. These three cases demonstrated that glue exposure causes active chronic inflammation with foreign body type granulomas, mucosal ulceration, and bleeding in the gastric mucosa. Even further, it can induce mass formation in the injection sites.
肉芽肿在胃活检中很少见，主要是由于结节病、克罗恩病、感染、肿瘤和血管炎等肉芽肿性疾病累及所致。在此，我们指出氰基丙烯酸酯是血管栓塞术后胃内引起异物型肉芽肿的一种介质。我们呈现3例与氰基丙烯酸酯相关的胃部改变：2例内镜活检和1例胃切除术。在2例中，分别于注射胶水7个月和6年后行内镜检查，在胃黏膜活检中观察到与氰基丙烯酸酯相关的溃疡和肉芽肿性炎症。在第3例中，在手术前2个月进行了氰基丙烯酸酯注射。随后患者因胰腺腺癌接受了远端胰腺切除术，术中切除了一个怀疑有肿瘤浸润的胃肿物。这3例病例表明，接触胶水会导致胃黏膜出现伴有异物型肉芽肿的活动性慢性炎症、黏膜溃疡和出血。甚至，它还可在注射部位诱发肿物形成。
