Yoon Seungyeon A, Weierich Mariann R
Hunter College, City University of New York, United States.
Neuroimage Clin. 2017 Jan 16;14:250-259. doi: 10.1016/j.nicl.2017.01.015. eCollection 2017.
We investigated the potential role of cingulum and uncinate fasciculus integrity in trauma-related neural hypervigilance, indexed by less discrimination between amygdala activation to novel and familiar affective images.
22 women (mean age 21.7 ± 3.9 years) with a history of trauma, and 20 no-trauma controls (mean age 21.9 ± 4.8 years).
Trauma exposure and trauma-related symptoms were assessed during structured clinical interview. White matter integrity in the anterior cingulum, parahippocampal cingulum, and uncinate fasciculus was measured using diffusion weighted imaging. Amygdala response to novel and familiar affective scenes was measured with functional magnetic resonance imaging.
Trauma-exposed women showed less discrimination between novel and familiar negative images in the amygdala compared to no-trauma controls. In trauma-exposed women, less amygdala discrimination between novel and familiar affective images was associated with less structural integrity in the anterior cingulum, but was not associated with structural integrity of the parahippocampal cingulum or the uncinate fasciculus.
The anterior cingulum might play an important role in impaired novelty discrimination for affective information in the amygdala. This impairment is potentially driven by inefficient habituation and could contribute to persistent behavioral hypervigilance following trauma exposure.
我们研究了扣带束和钩束完整性在创伤相关神经高度警觉中的潜在作用，以杏仁核对新的和熟悉的情感图像激活的辨别力降低为指标。
22名有创伤史的女性（平均年龄21.7±3.9岁）和20名无创伤对照组（平均年龄21.9±4.8岁）。
在结构化临床访谈中评估创伤暴露和创伤相关症状。使用扩散加权成像测量前扣带束、海马旁扣带束和钩束中的白质完整性。用功能磁共振成像测量杏仁核对新的和熟悉的情感场景的反应。
与无创伤对照组相比，有创伤暴露的女性在杏仁核对新的和熟悉的负面图像的辨别力较低。在有创伤暴露的女性中，杏仁核对新的和熟悉的情感图像的辨别力较低与前扣带束的结构完整性较低有关，但与海马旁扣带束或钩束的结构完整性无关。
前扣带束可能在杏仁核对情感信息的新奇辨别受损中起重要作用。这种损害可能是由低效的习惯化驱动的，并可能导致创伤暴露后持续的行为高度警觉。
