日本（京都）自发性高血压大鼠的肾脏前列腺素生成

Renal prostaglandin production in the Japanese (Kyoto) spontaneously hypertensive rat.

Dunn M J

Clin Sci Mol Med Suppl. 1978 Dec;4:191s-193s. doi: 10.1042/cs055191s.

Abstract

Renal venous and urinary prostaglandin E2 (PGE2) and prostaglandin F2alpha (PGF2alpha) were measured in spontaneously hypertensive (SH) rats and Wistar-Kyoto normotensive rats (WKy) of 4 different ages, ranging from 4 to 54 weeks. 2. Renal venous (plasma) PGE2 and PGF2alpha were similar in WKy and SH rats at all ages, except for greater PGF2alpha in 40-54 week old SH rats. 3. Urinary (24 h) PGE2 and PGF2alpha were similar in WKy and SH rats at all ages, except for greater PGE2 in 7-12 week old SH rats. 4. There was a significant trend for renal venous and urinary PGE2 and PGF2alpha to decrease with advancing age. 5. These experiments did not show evidence that the SH rat kidney, in vivo, has an abnormality of PGE2 or PGF2alpha production or degradation, which alters secretion or excretion of either prostaglandin.

摘要

对4至54周龄的4种不同年龄的自发性高血压（SH）大鼠和Wistar-Kyoto正常血压大鼠（WKy），测定其肾静脉和尿液中的前列腺素E2（PGE2）和前列腺素F2α（PGF2α）。2. 在所有年龄段，WKy大鼠和SH大鼠肾静脉（血浆）中的PGE2和PGF2α相似，但40至54周龄的SH大鼠中PGF2α含量更高。3. 在所有年龄段，WKy大鼠和SH大鼠尿液（24小时）中的PGE2和PGF2α相似，但7至12周龄的SH大鼠中PGE2含量更高。4. 肾静脉和尿液中的PGE2和PGF2α有随年龄增长而显著下降的趋势。5. 这些实验未显示出证据表明SH大鼠的肾脏在体内存在PGE2或PGF2α产生或降解异常，从而改变任何一种前列腺素的分泌或排泄。