使用L-sIDOL转基因小鼠作为研究高胆固醇血症和动脉粥样硬化的小鼠模型。
The Use of L-sIDOL Transgenic Mice as a Murine Model to Study Hypercholesterolemia and Atherosclerosis.
作者信息
Zerenturk Eser J, Calkin Anna C
机构信息
Lipid Metabolism and Cardiometabolic Disease Laboratory, Baker IDI Heart and Diabetes Institute, St Kilda Rd Central, 6492, Melbourne, VIC, 3004, Australia.
Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
出版信息
Methods Mol Biol. 2017;1583:65-72. doi: 10.1007/978-1-4939-6875-6_6.
There are many advantages to the use of mice as a model to study the regulation of cholesterol metabolism. Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice. Herein, we describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis.
将小鼠作为研究胆固醇代谢调节的模型有许多优点。高胆固醇血症的常见模型包括低密度脂蛋白受体缺陷（LDLR -/-）小鼠和载脂蛋白E缺陷（ApoE -/-）小鼠。在此，我们描述了最近构建的小鼠模型，L-sIDOL Tg小鼠，其以肝脏特异性方式表达低密度脂蛋白受体诱导降解物（IDOL）的显性活性形式。与先前建立的用于研究高胆固醇血症和动脉粥样硬化的模型相比，这种小鼠模型具有显著优势。
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