Fan J, Shan Q, Wang J, Liu S, Li L, Zheng G
Key Laboratory of Tropical and Subtropical Fishery Resource Application and Cultivation of Ministry of Agriculture, Pearl River Fisheries Research Institute, Chinese Academic of Fishery Science, Guangzhou, China.
College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China.
J Vet Pharmacol Ther. 2017 Oct;40(5):580-582. doi: 10.1111/jvp.12392. Epub 2017 Feb 15.
The comparative pharmacokinetics of enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP) were investigated in healthy and Aeromonas hydrophila-infected crucian carp after a single oral (p.o.) administration at a dose of 10 mg/kg at 25 °C. The plasma concentrations of ENR and of CIP were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR concentrations by noncompartmental modeling. In healthy fish, the elimination half-life (T ), maximum plasma concentration (C ), time to peak (T ), and area under the concentration-time curve (AUC) values were 64.66 h, 3.55 μg/mL, 0.5 h, and 163.04 μg·h/mL, respectively. In infected carp, by contrast, the corresponding values were 73.70 h, 2.66 μg/mL, 0.75 h, and 137.43 μg·h/mL, and the absorption and elimination of ENR were slower following oral administration. Very low levels of CIP were detected, which indicates a low extent of deethylation of ENR in crucian carp.
在25℃下，以10 mg/kg的剂量对健康和嗜水气单胞菌感染的鲫鱼进行单次口服给药后，研究了恩诺沙星（ENR）及其代谢物环丙沙星（CIP）的比较药代动力学。通过高效液相色谱法测定ENR和CIP的血浆浓度。基于平均ENR浓度，通过非房室模型计算药代动力学参数。在健康鱼中，消除半衰期（T）、最大血浆浓度（C）、达峰时间（T）和浓度-时间曲线下面积（AUC）值分别为64.66小时、3.55μg/mL、0.5小时和163.04μg·h/mL。相比之下，在感染的鲤鱼中，相应的值分别为73.70小时、2.66μg/mL、0.75小时和137.43μg·h/mL，口服给药后ENR的吸收和消除较慢。检测到的CIP水平非常低，这表明鲫鱼中ENR的脱乙基程度较低。
