Hu D, Kang H, Lv Y, Zhang N, Tang L, Zhang J, Shi K, Wu R, Peng Y
Imaging Center, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Hematology Department, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Haemophilia. 2017 Mar;23(2):e99-e104. doi: 10.1111/hae.13159. Epub 2017 Feb 15.
Using diffusional kurtosis imaging (DKI) to assess the impact of emotional disorders on microstructural changes of the brain in children with haemophilia A.
Diffusional kurtosis imaging was acquired from haemophilia A (n = 22) and controls (n = 22) using a 3T scanner. A regression analysis of frontal, cingulate, hippocampus, insula and amygdala regions of interest (ROIs) was conducted. Clinical data and results of psychological tests were collected. A paired t-test was used to analyse the differences between the two groups' ROIs, and the Spearman test was used to analyse the correlation between ROIs and psychological tests or clinical data.
Fractional anisotropy (FA) in the left middle cingulate and right hippocampus; mean diffusion (MD) in the frontal lobe, right anterior cingulate and right middle cingulate showed varying degrees of increase in the ROI compared to controls (P < 0.003). MD in the frontal lobe and the course of disease (P < 0.05), FA in the right hippocampus and the social score of the self-consciousness scale (P < 0.01) had a positive correlation.
Our study is the first to evaluate the relationship between emotion disorders and cognitive changes in the microstructure of the brain in children with haemophilia A, suggesting that DKI provides more information about tissue microstructural changes than do the conventional image method and traditional psychological tests.
运用扩散峰度成像（DKI）评估甲型血友病患儿情绪障碍对脑微观结构变化的影响。
使用3T扫描仪对22例甲型血友病患儿和22例对照者进行扩散峰度成像。对额叶、扣带回、海马体、脑岛和杏仁核感兴趣区（ROI）进行回归分析。收集临床数据和心理测试结果。采用配对t检验分析两组ROI之间的差异，采用Spearman检验分析ROI与心理测试或临床数据之间的相关性。
与对照组相比，左侧中扣带回和右侧海马体的分数各向异性（FA）；额叶、右侧前扣带回和右侧中扣带回的平均扩散率（MD）在ROI中呈现不同程度的升高（P < 0.003）。额叶的MD与病程（P < 0.05）、右侧海马体的FA与自觉量表的社交得分（P < 0.01）呈正相关。
本研究首次评估了甲型血友病患儿情绪障碍与脑微观结构认知变化之间的关系，表明DKI比传统图像方法和传统心理测试能提供更多关于组织微观结构变化的信息。
