镰状细胞贫血患儿的微量元素：一项病例对照研究。
Trace elements in children suffering from sickle cell anemia: A case-control study.
作者信息
Sungu Joseph K, Mukuku Olivier, Mutombo Augustin Mulangu, Mawaw Paul, Aloni Michel N, Luboya Oscar N
机构信息
Department of Pediatrics, University Hospital of Lubumbashi, University of Lubumbashi, Kinshasa, the Democratic Republic of Congo.
School of Public Health, University of Lubumbashi, Lubumbashi, the Democratic Republic of Congo.
出版信息
J Clin Lab Anal. 2018 Jan;32(1). doi: 10.1002/jcla.22160. Epub 2017 Feb 15.
BACKGROUND
Information on serum albumin and trace elements among children suffering from Sickle Cell Anemia (SCA) was poorly documented in Africa. The aim of this study was to describe and to compare different values of trace elements with published reports from other parts of the world.
METHODS
We carried out a case-control study. Seventy-six steady state children suffering from SCA (Hb-SS). One hundred and fifty-two children were recruited with 76 (cases, Hb-SS) and 76 (control, Hb-AA) to compare the data.
RESULTS
The mean age was 10.0 years (SD=5.4) in SCA children and 9.2 years (SD=4.7) in the control group. The mean level of zinc and magnesium were slightly lower in the Hb-SS group than in the Hb-AA group (P<.001).
CONCLUSION
The first literature about trace elements in SCA is briefly reported in Central Africa. In our midst, zinc, magnesium, and selenium deficiencies underline the need for their systematic among all children with SCA to identify patients with these deficiencies and provide early management.
背景
在非洲，关于镰状细胞贫血（SCA）患儿血清白蛋白和微量元素的信息记录较少。本研究的目的是描述并比较微量元素的不同值与世界其他地区已发表报告的差异。
方法
我们开展了一项病例对照研究。76名患有SCA（Hb-SS）的稳定期儿童。招募了152名儿童，其中76名（病例组，Hb-SS）和76名（对照组，Hb-AA）以比较数据。
结果
SCA患儿的平均年龄为10.0岁（标准差=5.4），对照组为9.2岁（标准差=4.7）。Hb-SS组锌和镁的平均水平略低于Hb-AA组（P<0.001）。
结论
中非简要报道了关于SCA中微量元素的首篇文献。在我们当中，锌、镁和硒缺乏凸显了在所有SCA患儿中对其进行系统检测的必要性，以识别这些缺乏症患者并提供早期管理。
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