Erhabor Osaro, Ogar Kevin, Erhabor Tosan, Dangana Amos
Department of Haematology, School of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria.
Medical Laboratory Science Council of Nigeria, Nigeria.
Hum Antibodies. 2019;27(3):143-154. doi: 10.3233/HAB-180360.
Sickle cell disease is a genetic disorder of haemoglobin causing myriad of pathology including anaemia.
The aim of this study was to evaluate some haematological parameters and trace elements of total of forty-five (45) children with Sickle cell disease attending Specialist Hospital Sokoto.
Twenty-five (25) apparently healthy children which were assessed as controls. The haematological parameters were determined using automated method and trace elements (copper and selenium) were determined using colorimetric and atomic absorption spectrophotometry method respectively.
The Mean WBC and PLT was significantly higher among sickle cell disease subjects when compared to controls individuals (p< 0.05). The Mean RBC, HCT, HGB, MCV, MCH and MCHC was significantly lower among Sickle cell disease patients when compared to controls (p< 0.05). The Mean Copper and Selenium value was significantly lower (40.4 ± 1.44 μg/dl and 54.6 ± 1.60 ng/ml) among Sickle cell disease subjects compared to controls (75.6 ± 1.30 μg/dl and 86.3 ± 2.30 ng/ml) (p< 0.05). The WBC, HGB, HGT and Copper values of Sickle cell disease subjects shows a weak positive put non-statistically significant correlation with age (p> 0.05). The RBC, MCV, MCH, MCHC, PLT, and Selenium values of sickle cell disease patients shows a negative non-statistically significant correlation indicating that the selenium level decreases as the age increases (p< 0.05).
This study shows that the WBC and platelet count was significantly higher among sickle cell disease subjects compared to controls. The RBC, HCT, HGB, MCV, MCH and MCHC were significantly lower among sickle cell disease patients compared to controls. The serum copper and selenium levels were significantly lower among sickle cell subjects compared to controls. We recommend that trace elements (copper and selenium) and haematological parameters be monitored routinely among sickle cell disease children to optimize the care offered to these individuals.
镰状细胞病是一种血红蛋白的遗传性疾病，会引发包括贫血在内的多种病理状况。
本研究旨在评估索科托专科医院的45名镰状细胞病患儿的一些血液学参数和微量元素。
选取25名明显健康的儿童作为对照。血液学参数采用自动化方法测定，微量元素（铜和硒）分别采用比色法和原子吸收分光光度法测定。
与对照组相比，镰状细胞病患者的白细胞和血小板平均计数显著更高（p < 0.05）。与对照组相比，镰状细胞病患者的红细胞、血细胞比容、血红蛋白、平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度显著更低（p < 0.05）。与对照组（75.6 ± 1.30 μg/dl和86.3 ± 2.30 ng/ml）相比，镰状细胞病患者的铜和硒平均水平显著更低（40.4 ± 1.44 μg/dl和54.6 ± 1.60 ng/ml）（p < 0.05）。镰状细胞病患者的白细胞、血红蛋白、血细胞比容和铜水平与年龄呈弱正相关，但无统计学意义（p > 0.05）。镰状细胞病患者的红细胞、平均红细胞体积、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度、血小板和硒水平呈负相关，但无统计学意义，表明硒水平随年龄增长而降低（p < 0.05）。
本研究表明，与对照组相比，镰状细胞病患者的白细胞和血小板计数显著更高。与对照组相比，镰状细胞病患者的红细胞、血细胞比容、血红蛋白、平均红细胞体积、平均红细胞血红蛋白含量和平均红细胞血红蛋白浓度显著更低。与对照组相比，镰状细胞病患者的血清铜和硒水平显著更低。我们建议对镰状细胞病患儿定期监测微量元素（铜和硒）和血液学参数，以优化对这些患儿的护理。
