State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210023, China.
Org Lett. 2017 Mar 3;19(5):1240-1243. doi: 10.1021/acs.orglett.7b00337. Epub 2017 Feb 16.
Radical alkynyltrifluoromethylation of alkenes with actylenic triflones has been achieved. This radical chain reaction is initiated by a catalytic amount of an electron-donor-acceptor complex composed of Togni's reagent and N-methylmorpholine. This transformation proceeds under exceptionally mild and operationally simple conditions. A variety of alkenes are compatible in this protocol including aliphatic alkenes, vinyl ethers, enecarbamates, styrenes, and even acrylates, providing diverse β- trifluoromethyl alkynes in good to excellent yields.
炔基三氟甲基化反应已经实现了烯烃的自由基炔基三氟甲基化。这个自由基链反应是由少量的电子给体-受体配合物引发的，该配合物由 Togni 试剂和 N-甲基吗啉组成。这种转化在非常温和和操作简单的条件下进行。各种烯烃在这个方案中都是相容的，包括脂肪族烯烃、乙烯基醚、烯基碳酸酯、苯乙烯，甚至丙烯酸酯，以良好至优秀的收率提供了各种β-三氟甲基炔。
