人类内源性逆转录病毒与多发性硬化症之间的关联：一项系统综述和荟萃分析。
The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis.
作者信息
Morandi Elena, Tanasescu Radu, Tarlinton Rachael E, Constantinescu Cris S, Zhang Weiya, Tench Christopher, Gran Bruno
机构信息
Division of Clinical Neuroscience, University of Nottingham School of Medicine, Nottingham, Nottingham, United Kingdom.
Division of Clinical Neurosciences, University of Medicine and Pharmacy Carol Davila, Department of Neurology, Colentina Hospital, Bucharest, Romania.
出版信息
PLoS One. 2017 Feb 16;12(2):e0172415. doi: 10.1371/journal.pone.0172415. eCollection 2017.
BACKGROUND
The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.
OBJECTIVE
To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.
METHODS
Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.
RESULTS
43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W (MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF.
CONCLUSIONS
This systematic review and meta-analysis shows an association between expression of HERVs, and in particular the HERV-W family, and MS.
背景
遗传因素与环境因素之间的相互作用对多发性硬化症（MS）的发病机制至关重要。人类内源性逆转录病毒（HERV）是人类基因组中的内源性病毒元件，其表达与MS相关。
目的
进行系统评价和荟萃分析，评估MS患者中HERV家族表达的定性和定量证据。
方法
检索Medline、Embase和Cochrane图书馆中关于HERV与MS关联的已发表研究。对HERV-W家族进行荟萃分析。计算关联的比值比（OR）和95%置信区间（CI）。
结果
提取了43篇报告（25篇与HERV-W相关，13篇与HERV-H相关，9篇与HERV-K相关，5篇与HRES-1相关，1篇与HER-15家族相关）。分析显示所有HERV家族的表达与MS之间存在关联。对于HERV-W，有足够的数据进行荟萃分析。对HERV-W进行荟萃分析的结果为：4项研究外周血单个核细胞中MSRV/HERV-W（MS相关逆转录病毒）包膜mRNA的OR = 22.66（95%CI 6.32至81.20），6项研究血清/血浆中MSRV/HERV-W聚合酶mRNA的OR = 44.11（95%CI 12.95至150.30），4项研究脑脊液中MSRV/HERV-W聚合酶mRNA的OR = 6.00（95%CI 3.35至10.74）。
结论
这项系统评价和荟萃分析表明HERV，特别是HERV-W家族的表达与MS之间存在关联。
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