虹膜中的衰老与α1肾上腺素能受体
Ageing and alpha 1 adrenoceptors in the iris.
作者信息
Buckley C, Curtin D M, Docherty J, Eustace P
机构信息
Research Department, Royal Victoria Eye and Ear Hospital, Dublin.
出版信息
Eye (Lond). 1987;1 ( Pt 2):211-6. doi: 10.1038/eye.1987.39.
PMID:2820809
Abstract
This study was undertaken to determine if the age related decrease in pupil size is attributable to altered sympathetic adrenoceptor responsiveness. Log dose response curves using the selective alpha 1 agonist phenylephrine and antagonist thymoxamine showed that there is no difference in alpha 1 adrenoceptor sensitivity in the elderly and the young. Therefore age related miosis is not caused by an alteration in alpha 1 receptors with age.
摘要
本研究旨在确定瞳孔大小随年龄增长而减小是否归因于交感肾上腺素能受体反应性的改变。使用选择性α1激动剂去氧肾上腺素和拮抗剂百里胺的对数剂量反应曲线表明，老年人和年轻人的α1肾上腺素能受体敏感性没有差异。因此，年龄相关的瞳孔缩小不是由α1受体随年龄的改变引起的。
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