Malavolti M, Ceryak S, Fromm H
Department of Medicine, George Washington University Medical Center, Washington, D.C. 20037.
Gastroenterology. 1987 Nov;93(5):1104-15. doi: 10.1016/0016-5085(87)90575-0.
The effects of both apolipoprotein B,E receptor-dependent and receptor-independent uptake of low-density lipoprotein (LDL) in the liver on bile secretion were studied in bile fistula hamsters. Three groups of animals were studied after 4 wk of feeding either a control, chenodeoxycholic acid-, or ursodeoxycholic acid-containing diet. The hepatic receptor-dependent and receptor-independent uptake of LDL was related to both bile flow and biliary lipid secretion. The correlation with bile flow and biliary lipid secretion was positive for the receptor-dependent, but negative for the receptor-independent uptake of LDL. Although the receptor-mediated LDL uptake appeared to exert a strong influence on bile acid-independent bile flow, the receptor-independent uptake showed a significant relation with biliary bile acid excretion. Differences between the two mechanisms of LDL uptake were also evident in the biliary bile acid-cholesterol coupling, which was significantly stronger during receptor-independent than during receptor-dependent uptake of LDL. The effects of LDL uptake on bile secretion were modulated by the experimentally induced changes in both the content and composition of bile acids in the enterohepatic circulation.
在胆瘘仓鼠中研究了肝脏中载脂蛋白B、E受体依赖性和非受体依赖性摄取低密度脂蛋白（LDL）对胆汁分泌的影响。给三组动物喂食对照饮食、含鹅去氧胆酸或熊去氧胆酸的饮食4周后进行研究。肝脏中LDL的受体依赖性和非受体依赖性摄取与胆汁流量和胆汁脂质分泌均有关。LDL的受体依赖性摄取与胆汁流量和胆汁脂质分泌呈正相关，而非受体依赖性摄取则呈负相关。尽管受体介导的LDL摄取似乎对非胆汁酸依赖性胆汁流量有强烈影响，但非受体依赖性摄取与胆汁中胆汁酸排泄有显著关系。LDL摄取的两种机制之间的差异在胆汁中胆汁酸-胆固醇偶联方面也很明显，在非受体依赖性摄取LDL期间比受体依赖性摄取期间显著更强。肠肝循环中胆汁酸的含量和组成的实验性诱导变化调节了LDL摄取对胆汁分泌的影响。
