Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Changzhou University , Changzhou 213164, China.
Anal Chem. 2017 Feb 7;89(3):1900-1906. doi: 10.1021/acs.analchem.6b04377. Epub 2017 Jan 19.
Construction of convenient systems for isomer discrimination is of great importance for medical and life sciences. Here, we report a simple and effective chiral sensing device based on a highly ordered self-assembly framework. Cu-modified β-cyclodextrin (Cu-β-CD) was self-assembled to the ammonia-ethanol cotreated chitosan (ae-CS), and the highly ordered framework was gradually formed during the "re-growth" process of the shrinked ae-CS films. Tryptophan (Trp) isomers were well discriminated with the highly ordered framework by electrochemical approach. This study is the first example showing how an ordered structure influences chiral recognition.
构建用于对映异构体识别的便捷系统对于医学和生命科学具有重要意义。在这里，我们报告了一种基于高度有序自组装框架的简单而有效的手性传感装置。Cu 修饰的 β-环糊精 (Cu-β-CD) 自组装到氨-乙醇共处理壳聚糖 (ae-CS) 上，并且在收缩的 ae-CS 薄膜的“再生长”过程中逐渐形成了高度有序的框架。通过电化学方法可以很好地区分色氨酸 (Trp) 异构体。该研究首次表明有序结构如何影响手性识别。
