Daum G S, Sullivan J L, Ansell J, Mulder C, Woda B A
Department of Pathology, University of Massachusetts Medical Center, Worcester 01605.
Hum Pathol. 1987 Oct;18(10):1071-4. doi: 10.1016/s0046-8177(87)80225-3.
Virus-associated hemophagocytic syndrome (VAHS) is a nonneoplastic, generalized histiocytic proliferation with marked hemophagocytosis associated with a systemic viral infection. Histologic studies of lymph nodes usually show lymphoid depletion and histiocytic proliferation. In this report we describe the case of a patient with Epstein-Barr virus-associated VAHS in which initial lymph node biopsy samples showed an immunoproliferative lesion that preceded the usual generalized histiocytic proliferation. This finding suggests that some cases of VAHS may have an immunoproliferative precursor lesion.
病毒相关性噬血细胞综合征（VAHS）是一种非肿瘤性全身性组织细胞增生，并伴有明显的噬血细胞现象，与全身性病毒感染相关。淋巴结的组织学研究通常显示淋巴细胞耗竭和组织细胞增生。在本报告中，我们描述了一例与爱泼斯坦-巴尔病毒相关的VAHS患者，其最初的淋巴结活检样本显示出一种免疫增殖性病变，该病变先于通常的全身性组织细胞增生出现。这一发现提示，某些VAHS病例可能存在免疫增殖性前驱病变。
