Bhatia M S, Saha Rashmita, Doval Nimisha
Director Professor and Head, Department of Psychiatry, University College of Medical Sciences & Guru Teg Bahadur Hospital , Dilshad Garden, Delhi, India .
Senior Resident, Department of Psychiatry, University College of Medical Sciences & Guru Teg Bahadur Hospital , Dilshad Garden, Delhi, India .
J Clin Diagn Res. 2016 Dec;10(12):VD01-VD02. doi: 10.7860/JCDR/2016/21803.9059. Epub 2016 Dec 1.
Agenesis of corpus callosum is rare and associated neuropsychiatric abnormalities reported are epilepsy, Asperger's syndrome, learning problems, depression, schizophrenia, conduct disorder and conversion symptoms. Schizophrenia is the most common psychiatric disorder reported among corpus callosum agenesis. We report a rare case of delusional disorder with corpus callosum agenesis and seizure disorder. The patient presented with delusions of persecution towards younger brother and mother, disturbed sleep and reduced appetite. She had a history of seizure disorder of ten years duration, which was controlled with carbamazepine and levetiracetam. Neurological examination was normal. On MRI, corpus callosum agenesis was detected. She was put on an atypical antipsychotic quetiapine to which her psychiatric symptoms responded completely.
胼胝体发育不全较为罕见，报告显示与之相关的神经精神异常包括癫痫、阿斯伯格综合征、学习问题、抑郁、精神分裂症、品行障碍和转换症状。精神分裂症是胼胝体发育不全病例中报告最多的精神疾病。我们报告一例罕见的伴有胼胝体发育不全和癫痫症的妄想障碍病例。该患者表现出迫害弟弟和母亲的妄想、睡眠障碍和食欲减退。她有长达十年的癫痫病史，通过卡马西平和左乙拉西坦控制病情。神经系统检查正常。磁共振成像（MRI）检查发现胼胝体发育不全。她开始服用非典型抗精神病药物喹硫平，其精神症状得到了完全缓解。
