Department of Radiology, Haydarpasa Numune Training and Research Hospital, 34668 Istanbul, Türkiye.
Department of Psychiatry, Erenkoy Psychiatry and Neurology Training and Research Hospital, 34736 Istanbul, Türkiye.
Actas Esp Psiquiatr. 2024 Jun;52(3):256-267. doi: 10.62641/aep.v52i3.1604.
The neurobiological basis of delusional disorder is less explored through neuroimaging techniques than in other psychotic disorders. This study aims to provide information about the neural origins of delusional disorder (DD) by examining the neuroanatomical features of some basal nuclei with magnetic resonance imaging (MRI) texture analysis.
Twenty DD patients and 20 healthy individuals were included in the study. Globus pallidus, putamen, and caudate nuclei were selected individually with a region of interest (ROI) on the axial MRI images. The entire texture analysis algorithm applied to all selected ROIs was done with an in-house software. Nuclei on both sides were taken as separate samples.
There were no significant differences between groups in terms of age and gender. The average "mean, median and maximum" values of all three nuclei were decreased in DD patients. The small putamen area and the differences detected in different tissue parameters for all three nuclei in delusional disorder patients indicate that they differ in delusional disorder from normal controls (p < 0.05).
The differences detected in the texture parameters for all three nuclei indicate that there is something different in the DD from in the normal controls. Neuroimaging studies with larger samples and different techniques in the future may shed light on the etiology of delusional disorder.
通过神经影像学技术对妄想障碍的神经生物学基础的研究不如其他精神病性障碍深入。本研究旨在通过检查一些基底核的神经解剖学特征，利用磁共振成像（MRI）纹理分析来提供有关妄想障碍（DD）神经起源的信息。
本研究纳入 20 例 DD 患者和 20 名健康个体。在轴向 MRI 图像上，使用感兴趣区（ROI）分别单独选择苍白球、壳核和尾状核。将整个纹理分析算法应用于所有选定的 ROI，并使用内部软件进行处理。将两侧的核作为单独的样本。
两组在年龄和性别方面无显著差异。DD 患者的所有三个核的“平均值、中位数和最大值”平均值均降低。妄想障碍患者的小壳核面积以及在所有三个核的不同组织参数中检测到的差异表明，它们与正常对照组不同（p < 0.05）。
所有三个核的纹理参数差异表明，DD 与正常对照组存在差异。未来采用更大样本和不同技术的神经影像学研究可能会阐明妄想障碍的病因。
