血压随年龄增长的生化关联。

Biochemical correlates of the increase in blood pressure with age.

Grim C E, Weinberger M H, Henry D P, Luft F C, Fineberg N S

Clin Sci Mol Med Suppl. 1978 Dec;4:377s-379s. doi: 10.1042/cs055377s.

Abstract

Blood pressure, plasma renin activity, plasma aldosterone, urinary noradrenaline during sleep (UNA-S) and several estimates of sodium intake were determined in 379 normotensive subjects (age 13--70) to investigate the relationship of these variables to blood pressure. 2. Blood pressure was correlated with age, weight, plasma renin activity UNA-S, and estimates of sodium intake. There variables were frequently intercorrelated. 3. Multiple-correlation analysis revealed that after removal of the effects of age, blood pressure was related to weight, plasma renin activity, UNA-S and estimates of sodium intake. 4. However, multiple-regression analysis failed to demonstrate an effect of plasma renin activity, UNA-S, or estimates of sodium intake on blood pressure when the effects of age, weight, race and sex were removed. 5. Careful matching of subjects by age, weight, race and sex in studies of blood pressure and biochemical factors in normal subjects is crucial to proper interpretation of such data.

摘要

对379名血压正常的受试者（年龄在13至70岁之间）测定了血压、血浆肾素活性、血浆醛固酮、睡眠期间尿去甲肾上腺素（UNA-S）以及几种钠摄入量的评估指标，以研究这些变量与血压之间的关系。2. 血压与年龄、体重、血浆肾素活性、UNA-S以及钠摄入量的评估指标相关。这些变量之间经常相互关联。3. 多元相关分析显示，在去除年龄影响后，血压与体重、血浆肾素活性、UNA-S以及钠摄入量的评估指标有关。4. 然而，当去除年龄、体重、种族和性别的影响后，多元回归分析未能证明血浆肾素活性、UNA-S或钠摄入量的评估指标对血压有影响。5. 在正常受试者的血压和生化因素研究中，按年龄、体重、种族和性别仔细匹配受试者对于正确解释此类数据至关重要。