通过质子核磁共振弛豫时间测定正常成年大鼠脑的细胞内和细胞外空间。

Intracellular and extracellular spaces of normal adult rat brain determined from the proton nuclear magnetic resonance relaxation times.

作者信息

Haida M, Yamamoto M, Matsumura H, Shinohara Y, Fukuzaki M

机构信息

Department of Neurology, Tokai University School of Medicine, Kanagawa, Japan.

出版信息

J Cereb Blood Flow Metab. 1987 Oct;7(5):552-6. doi: 10.1038/jcbfm.1987.104.

DOI:10.1038/jcbfm.1987.104

PMID:2821030

Abstract

The nuclear magnetic resonance method was used to investigate the state of water molecules in normal rat brain tissue in vitro. The transverse magnetization decay curve (TMDC) of the fresh brain tissue of adult rats (8- or 10-weeks-old) was biexponential, which could be interpreted in terms of two distinct transverse relaxation times (T2). Several factors that may affect the TMDC are discussed. It was concluded that the fast and slow components of T2 correspond to those of the water molecules of the intracellular and the extracellular spaces of normal rat brain tissue, respectively.

摘要

采用核磁共振方法研究正常大鼠脑组织在体外水分子的状态。成年大鼠（8或10周龄）新鲜脑组织的横向磁化衰减曲线（TMDC）呈双指数形式，这可以用两个不同的横向弛豫时间（T2）来解释。讨论了几个可能影响TMDC的因素。得出的结论是，T2的快成分和慢成分分别对应于正常大鼠脑组织细胞内和细胞外空间水分子的成分。