Chirappapha Prakasit, Kitudomrat Saowanee, Thongjood Thanaporn, Aroonroch Rangsima
Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Dental Department, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Gland Surg. 2017 Feb;6(1):93-100. doi: 10.21037/gs.2016.07.04.
Bisphosphonates (BPs) are indicated to treat skeletal-related events (SREs) for cancer patients with bone metastasis. We report a 79-year-old woman with advanced stage breast cancer with bone metastasis who was prescribed BPs (zoledronate), then developed osteonecrosis of jaw. We provide a brief review of the pathogenesis, diagnosis and treatment of this complication.
双膦酸盐类药物(BPs)被用于治疗骨转移癌患者的骨相关事件(SREs)。我们报告了一名79岁晚期乳腺癌伴骨转移的女性患者,她接受了BPs(唑来膦酸)治疗,随后发生了颌骨坏死。我们对该并发症的发病机制、诊断和治疗进行简要综述。