Does Massive Antigen Burden Allow Hepatic Viruses to Induce Regulatory T Cells and Their Tolerance and Persistence?
作者信息
Kaplan David E
机构信息
Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
出版信息
Cell Mol Gastroenterol Hepatol. 2015 Apr 16;1(3):259-261. doi: 10.1016/j.jcmgh.2015.03.004. eCollection 2015 May.
Abstract
摘要
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Does Massive Antigen Burden Allow Hepatic Viruses to Induce Regulatory T Cells and Their Tolerance and Persistence?大量抗原负荷是否会使肝病毒诱导调节性T细胞及其耐受性和持续性？
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本文引用的文献
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Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells.肝脏中病毒抗原的表达通过调节性T细胞的产生导致慢性感染。
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2
Hepatic immune regulation and its involvement in viral hepatitis infection.肝脏免疫调节及其在病毒性肝炎感染中的作用。
Gastroenterology. 2014 May;146(5):1193-207. doi: 10.1053/j.gastro.2013.12.036. Epub 2014 Jan 8.
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The Tim-3/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis.Tim-3/galectin-9 通路参与伴刀豆球蛋白 A 诱导的肝炎小鼠模型中肝调节性 T 细胞的稳态。
Mol Immunol. 2014 Mar;58(1):85-91. doi: 10.1016/j.molimm.2013.11.001. Epub 2013 Dec 10.
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Animal models for hepatitis C.丙型肝炎动物模型。
Curr Top Microbiol Immunol. 2013;369:49-86. doi: 10.1007/978-3-642-27340-7_3.
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Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.RIG-I 样受体和核酸感应 TLR 途径在控制慢性病毒感染中的差异作用。
J Immunol. 2012 May 1;188(9):4432-40. doi: 10.4049/jimmunol.1103656. Epub 2012 Mar 23.
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Int Immunol. 2010 Jun;22(6):491-502. doi: 10.1093/intimm/dxq033. Epub 2010 Apr 21.
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Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection.持续性病毒感染后，CD4 T细胞的内在功能失调会迅速发生。
J Virol. 2005 Aug;79(16):10514-27. doi: 10.1128/JVI.79.16.10514-10527.2005.
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Induction of hepatic injury by hepatitis C virus-specific CD8+ murine cytotoxic T lymphocytes in transgenic mice expressing the viral structural genes.在表达病毒结构基因的转基因小鼠中，丙型肝炎病毒特异性CD8 + 小鼠细胞毒性T淋巴细胞诱导肝损伤。
Biochem Biophys Res Commun. 2003 Feb 7;301(2):330-7. doi: 10.1016/s0006-291x(02)03018-8.
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