• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Does Massive Antigen Burden Allow Hepatic Viruses to Induce Regulatory T Cells and Their Tolerance and Persistence?大量抗原负荷是否会使肝病毒诱导调节性T细胞及其耐受性和持续性？
Cell Mol Gastroenterol Hepatol. 2015 Apr 16;1(3):259-261. doi: 10.1016/j.jcmgh.2015.03.004. eCollection 2015 May.
2
Immunity, tolerance and autoimmunity in the liver: A comprehensive review.肝脏中的免疫、耐受和自身免疫：全面综述。
J Autoimmun. 2016 Jan;66:60-75. doi: 10.1016/j.jaut.2015.08.020. Epub 2015 Sep 7.
3
CD4 T cells in hepatic immune tolerance.肝免疫耐受中的 CD4 T 细胞。
J Autoimmun. 2010 Feb;34(1):23-8. doi: 10.1016/j.jaut.2009.08.006. Epub 2009 Aug 31.
4
Interferon-γ facilitates hepatic antiviral T cell retention for the maintenance of liver-induced systemic tolerance.干扰素-γ促进肝脏抗病毒T细胞的留存，以维持肝脏诱导的全身耐受性。
J Exp Med. 2016 May 30;213(6):1079-93. doi: 10.1084/jem.20151218. Epub 2016 May 2.
5
Liver sinusoidal endothelial cells: a new type of organ-resident antigen-presenting cell.肝窦内皮细胞：一种新型的器官驻留抗原呈递细胞。
Arch Immunol Ther Exp (Warsz). 2001;49 Suppl 1:S7-11.
6
Mechanisms of tolerance induced by transforming growth factor-beta-treated antigen-presenting cells: CD8 regulatory T cells inhibit the effector phase of the immune response in primed mice through a mechanism involving Fas ligand.转化生长因子-β处理的抗原呈递细胞诱导耐受的机制：CD8调节性T细胞通过涉及Fas配体的机制抑制致敏小鼠免疫反应的效应阶段。
Int Immunol. 2004 May;16(5):697-706. doi: 10.1093/intimm/dxh067. Epub 2004 Mar 29.
7
The Balance between CD8 T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose.肝脏中CD8 T细胞介导的腺相关病毒编码抗原清除与耐受之间的平衡取决于载体剂量。
Mol Ther. 2017 Apr 5;25(4):880-891. doi: 10.1016/j.ymthe.2017.02.014. Epub 2017 Mar 9.
8
Mechanisms of tolerance induced by TGF beta-treated APC: CD4 regulatory T cells prevent the induction of the immune response possibly through a mechanism involving TGF beta.经转化生长因子β处理的抗原呈递细胞诱导耐受的机制：CD4调节性T细胞可能通过涉及转化生长因子β的机制阻止免疫应答的诱导。
Eur J Immunol. 2004 Apr;34(4):1021-30. doi: 10.1002/eji.200324547.
9
The benefits of diversity: heterogenous DC populations allow for both immunity and tolerance.多样性的益处：异质性树突状细胞群体可实现免疫与耐受。
J Theor Biol. 2014 Sep 21;357:86-102. doi: 10.1016/j.jtbi.2014.04.034. Epub 2014 May 9.
10
Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells.肝脏中病毒抗原的表达通过调节性T细胞的产生导致慢性感染。
Cell Mol Gastroenterol Hepatol. 2015 Feb 24;1(3):325-341.e1. doi: 10.1016/j.jcmgh.2015.02.002. eCollection 2015 May.

本文引用的文献

1
Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells.肝脏中病毒抗原的表达通过调节性T细胞的产生导致慢性感染。
Cell Mol Gastroenterol Hepatol. 2015 Feb 24;1(3):325-341.e1. doi: 10.1016/j.jcmgh.2015.02.002. eCollection 2015 May.
2
Hepatic immune regulation and its involvement in viral hepatitis infection.肝脏免疫调节及其在病毒性肝炎感染中的作用。
Gastroenterology. 2014 May;146(5):1193-207. doi: 10.1053/j.gastro.2013.12.036. Epub 2014 Jan 8.
3
The Tim-3/galectin-9 pathway involves in the homeostasis of hepatic Tregs in a mouse model of concanavalin A-induced hepatitis.Tim-3/galectin-9 通路参与伴刀豆球蛋白 A 诱导的肝炎小鼠模型中肝调节性 T 细胞的稳态。
Mol Immunol. 2014 Mar;58(1):85-91. doi: 10.1016/j.molimm.2013.11.001. Epub 2013 Dec 10.
4
Animal models for hepatitis C.丙型肝炎动物模型。
Curr Top Microbiol Immunol. 2013;369:49-86. doi: 10.1007/978-3-642-27340-7_3.
5
Differential roles for RIG-I-like receptors and nucleic acid-sensing TLR pathways in controlling a chronic viral infection.RIG-I 样受体和核酸感应 TLR 途径在控制慢性病毒感染中的差异作用。
J Immunol. 2012 May 1;188(9):4432-40. doi: 10.4049/jimmunol.1103656. Epub 2012 Mar 23.
6
A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease.用于研究丙型肝炎病毒感染、免疫反应和肝病的人源化小鼠模型。
Gastroenterology. 2011 Apr;140(4):1334-44. doi: 10.1053/j.gastro.2011.01.001. Epub 2011 Jan 13.
7
Tissue macrophages suppress viral replication and prevent severe immunopathology in an interferon-I-dependent manner in mice.组织巨噬细胞以依赖干扰素-I 的方式抑制病毒复制并防止严重的免疫病理。
Hepatology. 2010 Jul;52(1):25-32. doi: 10.1002/hep.23640.
8
Immunomodulation by hepatitis C virus-derived proteins: targeting human dendritic cells by multiple mechanisms.丙型肝炎病毒衍生蛋白的免疫调节作用：通过多种机制靶向人类树突状细胞。
Int Immunol. 2010 Jun;22(6):491-502. doi: 10.1093/intimm/dxq033. Epub 2010 Apr 21.
9
Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection.持续性病毒感染后，CD4 T细胞的内在功能失调会迅速发生。
J Virol. 2005 Aug;79(16):10514-27. doi: 10.1128/JVI.79.16.10514-10527.2005.
10
Induction of hepatic injury by hepatitis C virus-specific CD8+ murine cytotoxic T lymphocytes in transgenic mice expressing the viral structural genes.在表达病毒结构基因的转基因小鼠中，丙型肝炎病毒特异性CD8 + 小鼠细胞毒性T淋巴细胞诱导肝损伤。
Biochem Biophys Res Commun. 2003 Feb 7;301(2):330-7. doi: 10.1016/s0006-291x(02)03018-8.

Does Massive Antigen Burden Allow Hepatic Viruses to Induce Regulatory T Cells and Their Tolerance and Persistence?

作者信息

Kaplan David E

机构信息

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

出版信息

Cell Mol Gastroenterol Hepatol. 2015 Apr 16;1(3):259-261. doi: 10.1016/j.jcmgh.2015.03.004. eCollection 2015 May.

DOI:10.1016/j.jcmgh.2015.03.004
PMID:28210677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5301269/
Abstract
摘要