Su Hang, Ma Xiaojing, Yin Jun, Wang Yufei, He Xingxing, Bao Yuqian, Zhou Jian, Jia Weiping
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 600 Yishan Road, Shanghai, 200233, China.
Department of Endocrinology and Metabolism, Kashgar Prefecture Second People's Hospital, Liberated South Road, Kashgar, 844000, Xinjiang Uygur Autonomous Region, China.
Acta Diabetol. 2017 May;54(5):463-470. doi: 10.1007/s00592-017-0968-z. Epub 2017 Feb 16.
Previous studies showed that serum 1,5-anhydroglucitol (1,5-AG) levels are significantly reduced in patients with diabetes mellitus (DM). However, it remains unclear how 1,5-AG levels acutely change in response to a glucose load. This study explored acute changes in 1,5-AG levels after a glucose load and the related influencing factors in individuals with differing degrees of glucose tolerance.
A total of 681 participants (353 without DM and 328 with DM) without a prior history of DM were enrolled. All participants underwent an oral glucose tolerance test. Fasting and postload (30, 60, 120, and 180 min) levels of plasma glucose, serum 1,5-AG, and insulin were measured.
In all participant groups, serum 1,5-AG levels were slightly elevated after a glucose load and reached peak values at 120 min after loading (all P < 0.05). Regression analysis showed that body weight was negatively associated with the difference between peak and baseline 1,5-AG levels (Δ1,5-AG, standardized β = -0.119, P < 0.01). A strong and positive association between 1,5-AG and Δ1,5-AG was also found independent of other confounding factors (standardized β = 0.376, P < 0.01). The ratio of the Δ1,5-AG to the 1,5-AG was higher in DM patients (7.3% [3.4-11.5%]) than in those without DM (6.2% [3.6-9.2%]).
In contrast to the established decline in 1,5-AG levels with long-term hyperglycemia, the present study showed that serum 1,5-AG levels slightly increased by 6-7% after a glucose load. Further studies in different 1,5-AG transport models are needed to investigate the relevant metabolic pathways.
先前的研究表明，糖尿病（DM）患者血清1,5 - 脱水葡萄糖醇（1,5 - AG）水平显著降低。然而，尚不清楚1,5 - AG水平在葡萄糖负荷后如何急性变化。本研究探讨了葡萄糖负荷后1,5 - AG水平的急性变化以及不同糖耐量个体中的相关影响因素。
共纳入681名无糖尿病既往史的参与者（353名无DM，328名有DM）。所有参与者均接受口服葡萄糖耐量试验。测量空腹及负荷后（30、60、120和180分钟）的血浆葡萄糖、血清1,5 - AG和胰岛素水平。
在所有参与者组中，葡萄糖负荷后血清1,5 - AG水平略有升高，并在负荷后120分钟达到峰值（所有P < 0.05）。回归分析表明，体重与1,5 - AG峰值与基线水平之差（Δ1,5 - AG）呈负相关（标准化β = -0.119，P < 0.01）。还发现1,5 - AG与Δ1,5 - AG之间存在强正相关，且独立于其他混杂因素（标准化β = 0.376，P < 0.01）。DM患者的Δ1,5 - AG与1,5 - AG之比（7.3% [3.4 - 11.5%]）高于无DM患者（6.2% [3.6 - 9.2%]）。
与长期高血糖导致1,5 - AG水平下降的既定情况相反，本研究表明葡萄糖负荷后血清1,5 - AG水平略有升高6 - 7%。需要在不同的1,5 - AG转运模型中进行进一步研究以探讨相关代谢途径。
