Thylstrup A
Community Dent Oral Epidemiol. 1978 Nov;6(6):329-37. doi: 10.1111/j.1600-0528.1978.tb01174.x.
By the use of a new classification system of dental fluorosis, primary and permanent teeth were examined in samples of children born in areas with 3.5, 6.0 and 21.0 parts/10(6) F- in the water supplies. The severity of dental fluorosis was lower than in the corresponding permanent teeth, but a significant increase in severity was noted with increasing concentration of fluoride in the drinking water. The distribution of dental fluorosis within the dentition followed the same pattern irrespective of fluoride content of the water. Thus, a progressive increase in severity was noted from the anterior to the posterior teeth. This pattern is presumably determined by variations in enamel thickness. The much thinner enamel layer of primary teeth may also explain the lower degree of dental fluorosis in these teeth rather than a maternal barrier to fluoride. The degree of dental fluorosis observed in medium and high fluoride areas did not support the hypothesis that the rapidly growing skeleton of infants prevents fluoride-derived enamel changes.
通过使用一种新的氟斑牙分类系统，对出生在供水氟含量分别为3.5、6.0和21.0 ppm（每10⁶份含氟份数）地区的儿童样本中的乳牙和恒牙进行了检查。氟斑牙的严重程度低于相应的恒牙，但随着饮用水中氟浓度的增加，严重程度显著增加。无论水中氟含量如何，牙列中氟斑牙的分布模式相同。因此，从门牙到后牙，严重程度逐渐增加。这种模式可能由釉质厚度的变化决定。乳牙釉质层薄得多也可能解释了这些牙齿中氟斑牙程度较低的原因，而不是母体对氟的屏障作用。在中高氟地区观察到的氟斑牙程度并不支持婴儿快速生长的骨骼可防止氟导致釉质变化这一假说。
