Nowakowski Jarosław, Chrobak Adrian Andrzej, Dudek Dominika
Uniwersytet Jagielloński, Collegium Medicum.
Katedra Psychiatrii UJ CM.
Psychiatr Pol. 2016 Dec 23;50(6):1157-1166. doi: 10.12740/PP/62382.
Inflammatory bowel disease is a group of chronic medical conditions comprising Crohn's disease and ulcerative colitis that involves increased frequency of mental disorders. The most common psychiatric disorders in inflammatory bowel disease are depression and anxiety, however, some epidemiologic and biological evidence suggest that other disorders like bipolar disorder occur more often. Biological mechanisms concerning both inflammatory bowel disease and depression or anxiety explain susceptibility to developing mental disorders in inflammatory bowel disease. Interactions of brain gut-axis, immunological disturbances, oxidative stress and vagus nerve dysfunction play a role in pathophysiology of inflammatory bowel disease and mental disorders as well. Significance of these factors was covered in this paper. Psychiatric comorbidity in IBD may affect course of intestinal disease. It can increase requency and severity of relapses and hinder the treatment so knowledge about relationship between IBD and mental health appears to be vital for proper management of patients with inflammatory bowel disease.
炎症性肠病是一组慢性疾病，包括克罗恩病和溃疡性结肠炎，这些疾病常伴有精神障碍发病率的增加。炎症性肠病中最常见的精神障碍是抑郁和焦虑，然而，一些流行病学和生物学证据表明，双相情感障碍等其他疾病的发生更为频繁。炎症性肠病与抑郁或焦虑相关的生物学机制解释了炎症性肠病患者易患精神障碍的原因。脑-肠轴的相互作用、免疫紊乱、氧化应激和迷走神经功能障碍在炎症性肠病和精神障碍的病理生理学中也发挥着作用。本文涵盖了这些因素的重要性。炎症性肠病中的精神共病可能会影响肠道疾病的病程。它会增加复发的频率和严重程度，并阻碍治疗，因此了解炎症性肠病与心理健康之间的关系对于炎症性肠病患者的合理管理似乎至关重要。
