Zhang Yingyi, Kong Zhe, Zhang Yalong, Huang Wenhua, Wu Hai, Wan Xuechao, Li Yao
Department of Oncology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, China.
Cancer Biomark. 2017;19(2):145-150. doi: 10.3233/CBM-160166.
Prostate cancer (PCa) was one of the most common cancers in males in China. Long non-coding RNAs (lncRNA), a class of non-coding RNAs with more than 200 nucleotides, played key roles in the progression of prostate cancer. GLIDR, a novel long intergenic ncRNA, was found to be upregulated in tumors compared to normal tissues by using publically databases. In the clinical validation cohort, our results showed GLIDR was significantly up-regulated in prostate cancer samples and cell lines. To explore the potential functions of the GLIDR, we constructed gene co-expression networks and applied GO analysis. Our analysis revealed that GLIDR was involved in the regulation of translational elongation, transcription, rRNA processing, RNA splicing, signal transduction, and cell adhesion. Furthermore, a GLIDR-mediated ceRNA network in prostate cancer was also identified. We believed that this study still provided some clues in exploring new therapeutic and prognostic targets for prostate cancer.
前列腺癌（PCa）是中国男性中最常见的癌症之一。长链非编码RNA（lncRNA）是一类长度超过200个核苷酸的非编码RNA，在前列腺癌的进展中起关键作用。通过使用公开数据库发现，一种新型的长基因间ncRNA——GLIDR，在肿瘤组织中相比于正常组织呈上调表达。在临床验证队列中，我们的结果显示GLIDR在前列腺癌样本和细胞系中显著上调。为了探究GLIDR的潜在功能，我们构建了基因共表达网络并进行了基因本体（GO）分析。我们的分析表明，GLIDR参与翻译延伸、转录、rRNA加工、RNA剪接、信号转导和细胞黏附的调控。此外，还鉴定了前列腺癌中由GLIDR介导的竞争性内源RNA（ceRNA）网络。我们认为这项研究仍为探索前列腺癌新的治疗和预后靶点提供了一些线索。
