Arvin A M, Solem S M, Koropchak C M, Kinney-Thomas E, Paryani S G
Department of Pediatrics, Stanford University School of Medicine, California 94305.
J Gen Virol. 1987 Sep;68 ( Pt 9):2449-54. doi: 10.1099/0022-1317-68-9-2449.
Strain 2 guinea-pigs were inoculated with infectious varicella-zoster virus (VZV) or with immunoaffinity-purified proteins of VZV. Monoclonal antibodies to the VZV gpI (90,000/58,000 complex) and to a non-glycosylated protein, p170, were used to prepare the polypeptide antigens. Humoral and cell-mediated immune responses to the infectious virus were compared with those elicited by the gpI and p170 proteins. Both VZV IgG antibody production and T lymphocyte proliferation to VZV were detected after immunization with infectious VZV and with VZV proteins. The antibody and T lymphocyte responses waned after protein immunization in comparison with the responses induced by infectious VZV but were detected again immediately after reimmunization with gpI or p170.
