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[墨西哥城一家毒理学中心的儿童磷化锌中毒情况]

[Zinc phosphide poisoning in pediatric patients from a Toxicology Center at Mexico City].

作者信息

Sánchez-Villegas María Carmen Socorro, Bárcena-Ruiz Alejandro

机构信息

Departamento Clínico de Toxicología, Hospital General "Dr. Gaudencio González Garza", Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Ciudad de México, México.

出版信息

Rev Med Inst Mex Seguro Soc. 2017;55 Suppl 1:S44-S52.

Abstract

BACKGROUND

Zinc phosphide is a chemical compound that is frequently used as a rodenticide; it is a highly toxic product that is widely used, among other spaces, at home. Given that it is a highly commercialized pesticide and that there is no antidote, it is mandatory to establish favorably the clinical manifestations of the intoxication. The aim was to describe the epidemiological and clinical profile of children intoxicated with zinc phosphide attended in a toxicological center of a tertiary referral hospital.

METHODS

Cross-sectional, retrospective and observational study based on the medical records of 36 pediatric patients attended from 2005 to 2015 at the Centro de Información y Atención Toxicológica from Hospital General "Dr. Gaudencio González Garza", which belongs to the Instituto Mexicano del Seguro Social.

RESULTS

The study didn't show a prevalence of gender; 66% of patients were children between ages 1 and 2. 96% of patients were healthy and three adolescents used the product with suicidal purposes. Zinc phosphide exposure occurred at home. Toxicity was characterized by hypotension, hypoglycemia, metabolic acidosis, abdominal pain, nausea, and vomiting; none of the patients died. In addition, neither required mechanical ventilation nor hemodialysis.

CONCLUSION

The lack of knowledge of the potential toxicity of zinc phosphide and the fact that is easily reached at home allow the exposure to this product; it is an absolutely preventable risk.

摘要

背景

磷化锌是一种常用作灭鼠剂的化合物;它是一种剧毒产品,除其他场所外,在家中也广泛使用。鉴于它是一种高度商业化的杀虫剂且没有解毒剂,必须明确中毒的临床表现。目的是描述在一家三级转诊医院的毒理学中心就诊的磷化锌中毒儿童的流行病学和临床特征。

方法

基于2005年至2015年在墨西哥社会保障局下属的“高登西奥·冈萨雷斯·加尔萨博士”综合医院毒理学信息与护理中心就诊的36例儿科患者的病历进行横断面、回顾性和观察性研究。

结果

该研究未显示出性别差异;66%的患者为1至2岁的儿童。96%的患者身体健康,3名青少年出于自杀目的使用了该产品。磷化锌暴露发生在家中。中毒的特征为低血压、低血糖、代谢性酸中毒、腹痛、恶心和呕吐;无一例患者死亡。此外,无人需要机械通气或血液透析。

结论

对磷化锌潜在毒性缺乏了解以及它在家中容易获取的事实使得人们容易接触到该产品;这是一种完全可预防的风险。

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