Department of Chemistry, College of Sciences, NC State University, Raleigh, NC 27695, USA; Comparative Medicine Institute, NC State University, Raleigh, NC 27695, USA.
Cell Chem Biol. 2017 Feb 16;24(2):121-122. doi: 10.1016/j.chembiol.2017.01.009.
In this issue of Cell Chemical Biology, Ishikawa et al. (2017) demonstrate that the loss of cell-surface anionic saccharides can impart resistance toward anticancer peptides. This study provides the first insight into potential resistance mechanisms toward cationic lytic peptides and highlights the important, yet previously unappreciated, role cell-surface glycans can play in cellular resistance mechanisms.
在本期《细胞化学生物学》中，Ishikawa 等人（2017）证明了细胞表面阴离子糖的缺失可以赋予癌细胞对抗癌肽的抗性。这项研究首次揭示了阳离子溶细胞肽潜在的耐药机制，并强调了细胞表面聚糖在细胞耐药机制中重要但以前未被重视的作用。
