神经营养因子受体与神经周围浸润：对具有神经周围浸润倾向的特定非谱系相关皮肤恶性肿瘤的分析

Neurotrophin Receptors and Perineural Invasion: Analyses in Select Lineage-Unrelated Cutaneous Malignancies With a Propensity for Perineural Invasion.

作者信息

Frydenlund N F, Mahalingam M

机构信息

University of Iowa Carver College of Medicine, Iowa City, IA, United States.

VA Consolidated Laboratories, West Roxbury, MA, United States.

出版信息

Vitam Horm. 2017;104:497-531. doi: 10.1016/bs.vh.2016.11.003. Epub 2016 Dec 13.

DOI:10.1016/bs.vh.2016.11.003

PMID:28215306

Abstract

In this chapter, we parse the literature on neurotrophins that have been implicated in the pathogenesis of perineural invasion (PNI) in select lineage-unrelated malignancies. We also detail evidence linking neurotrophins and their receptors (TrkA, RET, p75NGFR, and NCAM) to the pathogenesis of PNI in desmoplastic melanoma and cutaneous squamous cell carcinoma-both malignancies with an established propensity for PNI. Lastly, the clinical potential of neurotrophins as receptors for targeted therapies is explored.

摘要

在本章中，我们剖析了有关神经营养因子的文献，这些神经营养因子与特定谱系无关的恶性肿瘤中神经周围浸润（PNI）的发病机制有关。我们还详细阐述了将神经营养因子及其受体（TrkA、RET、p75NGFR和NCAM）与促纤维增生性黑色素瘤和皮肤鳞状细胞癌中PNI的发病机制相联系的证据——这两种恶性肿瘤都具有PNI的既定倾向。最后，探讨了神经营养因子作为靶向治疗受体的临床潜力。