Hayashi Hiroko, Kawata Takuya, Shimokawa Isao
Department of Pathology, Nagasaki University School of Medicine and Graduate School of Biomedical Science, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Department of Pathology, Nagasaki University School of Medicine and Graduate School of Biomedical Science, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
Pathol Res Pract. 2017 May;213(5):580-584. doi: 10.1016/j.prp.2016.12.025. Epub 2017 Jan 3.
Epithelial type malignant mesothelioma with a clear cell morphology is rare, and no case arising in the peritoneum of a female patient has been reported. Here we report a case of clear cell mesothelioma that developed in the peritoneum of a 61-year-old female. The patient died from massive ascites and respiratory failure 11days after her hospital admission. The autopsy demonstrated marked thickening of the omentum and a yellowish-whitish tumor diffusely covering the abdominal organs. The predominantly solid tumor was characterized microscopically by the growth of atypical cells with an abundant clear cytoplasm. The immunohistochemical study suggested mesothelioma rather than carcinoma. Electron microscopy showed the long and slender villi of the tumor cells, confirming the diagnosis. Primary clear cell carcinoma of the peritoneum, like clear cell mesothelioma, is rare and was also a diagnostic consideration in this patient. The differentiation between these two tumors is discussed herein.
具有透明细胞形态的上皮型恶性间皮瘤较为罕见，且尚未有发生于女性患者腹膜的病例报道。在此，我们报告一例发生于一名61岁女性腹膜的透明细胞间皮瘤病例。该患者入院11天后死于大量腹水和呼吸衰竭。尸检显示大网膜显著增厚，有一个黄白色肿瘤弥漫性覆盖腹部器官。以实性为主的肿瘤在显微镜下的特征为非典型细胞生长，胞质丰富且透明。免疫组化研究提示为间皮瘤而非癌。电子显微镜显示肿瘤细胞有长而细的绒毛，证实了诊断。腹膜原发性透明细胞癌与透明细胞间皮瘤一样罕见，也是该患者的诊断考虑之一。本文讨论了这两种肿瘤的鉴别诊断。
