Roghmann Mary-Claire, Lydecker Alison D, Langenberg Patricia, Mongodin Emmanuel F, Johnson J Kristie
Geriatrics Research Education and Clinical Center, VA Maryland Health Care System, Baltimore, MD, 21201; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201.
Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, 21201.
Diagn Microbiol Infect Dis. 2017 May;88(1):53-57. doi: 10.1016/j.diagmicrobio.2017.02.005. Epub 2017 Feb 13.
To compare the presence of Staphylococcus aureus and pathogenic Gram-negative rods (GNR) in the anterior nares, posterior pharynx and three skin sites in community-based adults and nursing home-based adults before and after treatment with nasal mupirocin and topical chlorhexidine.
S. aureus-colonized adults were recruited from the community (n=26) and from nursing homes (n=8). Eligible participants were cultured for S. aureus and GNR during two study visits and then received intranasal mupirocin and topical chlorhexidine for 5days, with a 2-month follow-up period.
After decolonization, we found sustained decreases of S. aureus colonization in nose, throat and skin sites over 4-8weeks in both populations. Intranasal mupirocin did not increase GNR colonization in nose or throat. Chlorhexidine did not decrease GNR colonization in skin sites.
Decolonization with mupirocin and chlorhexidine leads to a sustained effect on S. aureus colonization without affecting GNR colonization.
比较在接受鼻用莫匹罗星和外用洗必泰治疗前后，社区成年人和养老院成年人的前鼻孔、后咽部及三个皮肤部位金黄色葡萄球菌和致病性革兰氏阴性杆菌（GNR）的存在情况。
从社区（n = 26）和养老院（n = 8）招募金黄色葡萄球菌定植的成年人。符合条件的参与者在两次研究访视期间进行金黄色葡萄球菌和GNR培养，然后接受鼻用莫匹罗星和外用洗必泰治疗5天，并进行为期2个月的随访。
去定植后，我们发现两组人群在4 - 8周内，鼻腔、咽喉和皮肤部位的金黄色葡萄球菌定植持续减少。鼻用莫匹罗星未增加鼻腔或咽喉部的GNR定植。洗必泰未减少皮肤部位的GNR定植。
莫匹罗星和洗必泰去定植对金黄色葡萄球菌定植有持续效果，且不影响GNR定植。
