Scarpace P J, Armbrecht H J
Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Sepulveda, California 91343.
Rev Clin Basic Pharm. 1987 Apr-Jun;6(2):105-18. doi: 10.1515/jbcpp.1987.6.2.105.
There are significant changes in the adenylate cyclase complex of many tissues with age. These changes are not due to a single defect in the system. Rather, the defects may vary from tissue to tissue and may be multiple in nature. There are age-related changes described in the receptor, N-protein, and catalytic components of the adenylate cyclase receptor. Alteration of the level of the receptor may reflect increases in the circulating levels of the agonist with age. The mechanisms responsible for alterations in the N-protein and catalytic unit activity remain to be elucidated. Further work is also needed to determine if the age-related changes in cAMP production result in age-related changes in cAMP-dependent protein kinase activity and the phosphorylation of specific proteins. However, the age-related changes in adenylate cyclase activity that have already been described may at least partially explain the decreased responsiveness of some target tissues to hormones and drugs.
随着年龄增长，许多组织的腺苷酸环化酶复合物会发生显著变化。这些变化并非由于该系统中的单一缺陷。相反，缺陷可能因组织而异，并且在性质上可能是多方面的。在腺苷酸环化酶受体的受体、N蛋白和催化成分中均有与年龄相关的变化描述。受体水平的改变可能反映了随着年龄增长激动剂循环水平的增加。N蛋白和催化单位活性改变的机制仍有待阐明。还需要进一步的研究来确定cAMP产生的年龄相关变化是否会导致cAMP依赖性蛋白激酶活性以及特定蛋白质磷酸化的年龄相关变化。然而，已经描述的腺苷酸环化酶活性的年龄相关变化可能至少部分解释了一些靶组织对激素和药物反应性降低的原因。
