Serrano Antonio, Hammadeh Hamzeh H, Herzog Stephanie, Illgen Julia, Schumann Marcel R, Weichert Martin, Fleiβner André
Institut für Genetik, Technische Universität Braunschweig, Spielmannstraβe 7, 38106 Braunschweig, Germany.
Institut für Genetik, Technische Universität Braunschweig, Spielmannstraβe 7, 38106 Braunschweig, Germany.
Fungal Genet Biol. 2017 Apr;101:31-33. doi: 10.1016/j.fgb.2017.02.003. Epub 2017 Feb 16.
Colony initiation of filamentous fungi commonly involves fusion of germinating vegetative spores. Studies in Neurospora crassa revealed an unusual cell-cell communication mechanism mediating this process, in which the fusion partners coordinately alternate between two physiological stages, probably related to signal sending and receiving. This "cell dialog" involves the alternating, oscillatory recruitment of the SO protein and the MAK-2 MAP kinase module to the apical plasma membrane of growing fusion tips. In this review video article, we show the dynamics of the fluorescent labeled proteins SO and MAK-2 and provide an animated graphical model of the "cell dialog" process.
丝状真菌的菌落起始通常涉及萌发的营养孢子的融合。对粗糙脉孢菌的研究揭示了一种介导这一过程的异常细胞间通讯机制，其中融合伙伴在两个生理阶段之间协调交替，这可能与信号发送和接收有关。这种“细胞对话”涉及SO蛋白和MAK-2丝裂原活化蛋白激酶模块在生长的融合尖端顶端质膜上的交替、振荡募集。在这篇综述视频文章中，我们展示了荧光标记蛋白SO和MAK-2的动态，并提供了“细胞对话”过程的动画图形模型。
