March Brayden, Calopedos Ross John Spero, Latif Edward, Ouyang Rupert
Department of Urology, Gosford Hospital, Gosford, NSW, Australia.
Department of Urology, Gosford Hospital, Gosford, NSW, Australia.
Urology. 2017 May;103:e7-e8. doi: 10.1016/j.urology.2017.02.021. Epub 2017 Feb 16.
We report the first documented case of malignant melanoma obstructing ureters of both moieties of a duplex kidney and contralateral single moiety ureter in a 51-year-old male. The patient presented with fever, coryzal symptoms, and liver function test derangement several years after 2 superficial spreading melanomas were excised with clear margins. Ultrasonography demonstrated hydronephroureter in both moieties of a complete right-sided duplex kidney. Retrograde pyelograms showed bilateral hydronephroureter and filling defects in all 3 ureters. Biopsied tumor cells were positive for S100, Melan A, and HMB45. Cutaneous melanoma metastasizing to ureters is a rare phenomenon and can present a diagnostic challenge to clinicians if clinically silent.
我们报告了首例有记录的恶性黑色素瘤阻塞双肾盂两部分及对侧单肾盂输尿管的病例，患者为一名51岁男性。该患者在2次切缘阴性的浅表扩散性黑色素瘤切除术后数年，出现发热、鼻卡他症状及肝功能检查紊乱。超声检查显示右侧完全性双肾盂两部分均有肾盂积水。逆行肾盂造影显示双侧肾盂积水及所有3条输尿管内充盈缺损。活检肿瘤细胞S100、Melan A和HMB45呈阳性。皮肤黑色素瘤转移至输尿管是一种罕见现象，若临床上无症状，可能给临床医生带来诊断挑战。
