Mureşan Ioan, Cosma Ioan
Department of Medical Clinic I, University of Medicine and Pharmacy, str. Clinicilor No. 3-5, 400006 Cluj-Napoca, Romania.
Department of Physics, Technical University, str. Memorandum No 28, 400114 Cluj-Napoca, Romania.
World J Nucl Med. 2017 Jan-Mar;16(1):8-14. doi: 10.4103/1450-1147.198238.
In this paper, we present an original radiocirculographic method for investigates of cerebral blood flow, which has proven to be very useful, simple, and efficient for studies of brain hemodynamics. Physical considerations on injected radioactive tracer in cardiovascular system, allowed us to state a relationship for the blood flux, F, valued as the amount of fluid-blood that traverses a vascular segment in unit time. All these theoretical facts, along with a host of remarkable clinical results, are presented in a doctoral thesis entitled "The cerebral Hemodynamics in Essential Hypertension and Arteriosclerosis" of the eminent doctor Ioan Mures,an, who died in 1984, at only 50 years old. Using tracers marked with radioactive chrome Cr and iodine I, it was studied, for patients with various vascular diseases the blood circulation in other territories as an echo of cerebral blood flow. Outstanding results, relating to physiology, diagnosis, and therapy of some diseases, have been obtained. Through intensive collaborations, this method has been operationalized at the University Clinics of Cluj. Here, thousands of patients have been investigated, obtaining quantifiable information which highlighted the patient's condition by emergent and incident blood flows in the global circulatory process and related to other vascular segments.
在本文中，我们提出了一种用于研究脑血流的独创放射循环造影方法，该方法已被证明在脑血流动力学研究中非常有用、简单且高效。基于心血管系统中注入的放射性示踪剂的物理考量，我们得以阐述血流量F的关系式，F被定义为单位时间内流经血管段的液体血液量。所有这些理论事实，连同大量卓越的临床结果，都呈现在著名医生伊万·穆雷斯安的博士论文《原发性高血压和动脉硬化中的脑血流动力学》中，他于1984年去世，年仅50岁。使用标记有放射性铬Cr和碘I的示踪剂，针对患有各种血管疾病的患者，研究了其他区域的血液循环作为脑血流的一种反映。已获得了与某些疾病的生理学、诊断和治疗相关的显著成果。通过紧密合作，该方法已在克卢日大学诊所投入使用。在此，数千名患者接受了检查，获得了可量化信息，这些信息通过整体循环过程中的紧急和偶然血流突出了患者的病情，并与其他血管段相关。
