Duong N, Torre P, Springer G, Cox C, Plankey M W
School of Medicine and Health Sciences, George Washington University, Washington, District of Columbia, USA.
School of Speech, Language, and Hearing Sciences, San Diego State University, San Diego, California, USA.
J AIDS Clin Res. 2016 Dec;7(12). doi: 10.4172/2155-6113.1000645. Epub 2016 Dec 19.
Research has established that human immunodeficiency virus (HIV) causes hearing loss. Studies have yet to evaluate the impact on quality of life (QOL). This project evaluates the effect of hearing loss on QOL by HIV status.
The study participants were from the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV study (WIHS). A total of 248 men and 127 women participated. Pure-tone air conduction thresholds were collected for each ear at frequencies from 250 through 8000 Hz. Pure-tone averages (PTAs) for each ear were calculated as the mean of air conduction thresholds in low frequencies (i.e., 250, 500, 1000 and 2000 Hz) and high frequencies (i.e., 3000, 4000, 6000 and 8000 Hz). QOL data were gathered with the Short Form 36 Health Survey and Medical Outcome Study (MOS)-HIV instrument in the MACS and WIHS, respectively. A median regression analysis was performed to test the association of PTAs with QOL by HIV status.
There was no significant association between hearing loss and QOL scores at low and high pure tone averages in HIV positive and negative individuals. HIV status, HIV biomarkers and treatment did not change the lack of association of low and high pure tone averages with poorer QOL.
Although we did not find a statistically significant association of hearing loss with QOL by HIV status, testing for hearing loss with aging and recommending treatment may offset any presumed later life decline in QOL.
研究已证实人类免疫缺陷病毒（HIV）会导致听力丧失。但尚未有研究评估其对生活质量（QOL）的影响。本项目通过HIV感染状况评估听力丧失对生活质量的影响。
研究参与者来自多中心艾滋病队列研究（MACS）和妇女机构间HIV研究（WIHS）。共有248名男性和127名女性参与。收集每只耳朵在250至8000赫兹频率下的纯音气导阈值。每只耳朵的纯音平均值（PTA）计算为低频（即250、500、1000和2000赫兹）和高频（即3000、4000、6000和8000赫兹）气导阈值的平均值。生活质量数据分别通过MACS中的简短健康调查36项和WIHS中的医疗结果研究（MOS）-HIV工具收集。进行中位数回归分析，以检验按HIV感染状况PTA与生活质量之间的关联。
在HIV阳性和阴性个体中，低频和高频纯音平均值下的听力丧失与生活质量得分之间无显著关联。HIV感染状况、HIV生物标志物和治疗并未改变低频和高频纯音平均值与较差生活质量之间缺乏关联的情况。
尽管我们未发现按HIV感染状况听力丧失与生活质量之间存在统计学上的显著关联，但对老年人进行听力丧失检测并推荐治疗可能会抵消任何假定的晚年生活质量下降。
