蛋白水解酶菠萝蛋白酶对拔除第三磨牙后疼痛和肿胀的影响。

Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars.

作者信息

Singh Tejpal, More Vinayak, Fatima Umayra, Karpe Tanveer, Aleem Mohammed A, Prameela J

机构信息

Department of Oral and Maxillofacial Surgery, Nanded Rural Dental College and Hospital, Ahmednagar, Maharashtra, India.

Department of Oral and Maxillofacial Surgery, Yashwant Rao Dental College and Hospital, Ahmednagar, Maharashtra, India.

出版信息

J Int Soc Prev Community Dent. 2016 Dec;6(Suppl 3):S197-S204. doi: 10.4103/2231-0762.197192.

AIMS AND OBJECTIVES

To evaluate the effect of bromelain on pain and swelling after surgical removal of third molars.

MATERIALS AND METHODS

A prospective randomized clinical study was conducted among 40 patients requiring surgical removal of impacted mandibular third molars. All the impacted molars were surgically removed, and the patients were administered bromelain along with amoxicillin. Patients were recalled on day 1, day 3, and day 7 for postoperative pain assessment using visual analogue scale (VAS) and postoperative swelling assessment using facial reference points tragus and pogonion. VAS score was statistically analyzed using repeated analysis of variance with post-hoc Bonferroni test postoperatively on day 1, day 3, and day 7 using the Statistical Package for the Social Sciences software version 14.

RESULTS

Out of the total 40 patients, bromelain was effective in 28 (70%) patients. In these patients, there was reduction in swelling and pain after taking bromelain.

CONCLUSION

Bromelain can be used as a successful oral enzyme therapy for oral surgery patients, especially after removal of impacted third molars.

目的

评估菠萝蛋白酶对拔除第三磨牙后疼痛和肿胀的影响。

材料与方法

对40例需要手术拔除下颌阻生第三磨牙的患者进行了一项前瞻性随机临床研究。所有阻生磨牙均通过手术拔除，患者在服用阿莫西林的同时服用菠萝蛋白酶。在术后第1天、第3天和第7天对患者进行回访，使用视觉模拟量表（VAS）评估术后疼痛，并使用面部参考点耳屏和颏前点评估术后肿胀。使用社会科学统计软件包第14版，对术后第1天、第3天和第7天的VAS评分进行重复方差分析，并进行事后Bonferroni检验，进行统计学分析。