一项使用原子力显微镜和磁力显微镜对非那西丁磁性活性固体分散体形成的研究。
A study of the formation of magnetically active solid dispersions of phenacetin using atomic and magnetic force microscopy.
作者信息
Usmanova Liana Stanislavovna, Ziganshin Marat Akhmedovich, Gorbatchuk Valery Vilenovich, Ziganshina Sufia Askhatovna, Bizyaev Dmitry Anatolevich, Bukharaev Anastas Akhmetovich, Mukhametzyanov Timur Anvarovich, Gerasimov Alexander Vladimirovich
机构信息
Department of Physical Chemistry, Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russia.
Kazan Scientific Center, E. K. Zavoisky Physical-Technical Institute, Russian Academy of Sciences, Kazan, Russia.
出版信息
J Adv Pharm Technol Res. 2017 Jan-Mar;8(1):2-7. doi: 10.4103/2231-4040.197331.
A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility. In this work, the distribution of superparamagnetic nanoparticles in the solid dispersion of polyethylene glycol with average molecular weight 950-1050 g/mol and phenacetin was studied using atomic force and magnetic force microscopy. The distribution of nanoparticles was found to be uniform in studied composites. Magnetically active solid dispersions may find application in the production of the capsulated drug delivery systems with enhanced solubility parameters.
许多药物的溶解度较差，这限制了它们向靶部位的吸收和分布，从而难以在不对健康细胞或组织产生不良影响的情况下引发预期作用。对于这类药物，必须开发新的给药方式，以便将药物高效、有效地递送至靶部位。形成这类药物的磁活性固体分散体可能是解决这一问题的有效方法，因为它们兼具靶向递送和良好的溶解性。在这项研究中，利用原子力显微镜和磁力显微镜研究了超顺磁性纳米颗粒在平均分子量为950 - 1050 g/mol的聚乙二醇与非那西丁的固体分散体中的分布情况。研究发现，纳米颗粒在复合材料中的分布是均匀的。磁活性固体分散体可能会应用于具有更高溶解度参数的胶囊化药物递送系统的生产中。
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