Salehi Marzieh, Salehi Maryam, Kalbasi Nader, Hakamifard Atousa, Salehi Hassan, Salehi Mohammad Mahdi, Sharifian Jalil
Department of Infectious Diseases, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Center, Dentistry School, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2017 Jan 31;6:8. doi: 10.4103/2277-9175.199259. eCollection 2017.
Mastitis is an inflammatory disorder in breast tissues due to bacterial factors, mycobacterial infections or autoimmune diseases. Idiopathic granulomatous mastitis (IGM) is a form of mastitis which may be affected by systematic diseases such as sarcoidosis, and infectious causes such as mycobacterium and fungus. This study evaluates the efficacy of medical therapy with a combination of corticosteroid and Azithromycin in patients with IGM.
This study is a clinical trial research carried out in Alzahra Hospital (Isfahan, Iran) in 2013 on granulomatous mastitis patients. It was administered 250 mg of Azithromycin per 12 hour and 60 mg of Prednisolone per day within 2 weeks. Next, they took 40 mg/day within 8 weeks, and this dosage was tapered during 6 months and the patients clinically and radiologically followed up. The studied patients were examined within 1 week, 2 weeks, 1 month, 3 months, and 6 months, from the beginning of treatment.
This study investigated granulomatous mastitis patients in Alzahra hospital in 2013. The mean age of these patients was 33.6 ± 8.9, and their age range was 18-56 years old. Among 26 studied patients, 24 persons (92.3%) according to follow-up the patients by physical examination and sonography responded to treatment of corticosteroid and Azithromycin. The remaining (7.7%) underwent surgery. Treatment periods in case of drug use were respectively, 8.5 ± 0.71 months.
Treatment with corticosteroid and Azithromycin is an effective and appropriate treatment for IGM.
乳腺炎是一种由细菌因素、分枝杆菌感染或自身免疫性疾病引起的乳腺组织炎症性疾病。特发性肉芽肿性乳腺炎（IGM）是乳腺炎的一种形式，可能受结节病等系统性疾病以及分枝杆菌和真菌等感染因素影响。本研究评估皮质类固醇与阿奇霉素联合药物治疗IGM患者的疗效。
本研究是2013年在伊朗伊斯法罕的阿尔扎赫拉医院对肉芽肿性乳腺炎患者进行的一项临床试验研究。在2周内每12小时给予250毫克阿奇霉素，每天给予60毫克泼尼松龙。接下来，在8周内每天服用40毫克，该剂量在6个月内逐渐减少，并对患者进行临床和影像学随访。从治疗开始起，在1周、2周、1个月、3个月和6个月对研究患者进行检查。
本研究调查了2013年阿尔扎赫拉医院的肉芽肿性乳腺炎患者。这些患者的平均年龄为33.6±8.9岁，年龄范围为18 - 56岁。在26名研究患者中，根据体格检查和超声对患者进行随访，24人（92.3%）对皮质类固醇和阿奇霉素治疗有反应。其余（7.7%）接受了手术。使用药物治疗的疗程分别为8.5±0.71个月。
皮质类固醇和阿奇霉素治疗是IGM的一种有效且合适的治疗方法。
