Bonifazi F, Antonicelli L, Pieretti C, Piunti E, Rossini R, Patalano F, Ruggieri F
Allergy Respiratory Unit, Regional General Hospital, Rome, Italy.
Allergol Immunopathol (Madr). 1987 May-Jun;15(3):151-3.
In a double-blind crossover placebo controlled study, the inhibitory effects of three different doses of nedocromil sodium on the immediate bronchoconstrictor response to antigen challenge were compared with a placebo. All the test treatments were inhaled three hours before challenge. Four asthmatic patients took part in the study and the test treatments were taken in a randomized order. All three doses of nedocromil sodium significantly reduced the bronchoconstrictor response and protected the patients against antigen challenge, compared with placebo. The highest dose of 2 mg was the most effective dose. All test doses of nedocromil sodium were safe and well tolerated by the patients.
