Richmond Abby M, Mehrotra Sanjana
Department of Pathology, University of Colorado, Aurora, Colorado.
Diagn Cytopathol. 2017 Apr;45(4):371-378. doi: 10.1002/dc.23662. Epub 2017 Feb 20.
Endoscopic ultrasound-guided fine-needle aspiration is increasingly utilized for the diagnosis of pancreatic lesions. Although operator dependent, the procedure has good overall performance characteristics and is minimally invasive; however, accuracy and sensitivity are reportedly lower for pancreatic neuroendocrine tumor (PanNET) compared with the more common pancreatic ductal adenocarcinoma (pACA). The underperformance is further exacerbated by the unusual cases of PanNET presenting with variant cytomorphology. We report two separate diagnostically challenging cases: a pigmented PanNET and a clear cell PanNET. We briefly review the literature and emphasize the importance of recognizing these uncommon variants when encountered in aspirate material. Diagn. Cytopathol. 2017;45:371-378. © 2016 Wiley Periodicals, Inc.
内镜超声引导下细针穿刺越来越多地用于胰腺病变的诊断。尽管该操作依赖于操作者，但总体性能良好且微创；然而，据报道，与更常见的胰腺导管腺癌（pACA）相比，胰腺神经内分泌肿瘤（PanNET）的准确性和敏感性较低。PanNET出现细胞形态变异的不寻常病例进一步加剧了这种表现不佳的情况。我们报告了两例诊断具有挑战性的病例：一例色素沉着型PanNET和一例透明细胞型PanNET。我们简要回顾了文献，并强调在吸出物中遇到这些罕见变异时识别它们的重要性。《诊断细胞病理学》2017年；45:371 - 378。©2016威利期刊公司
