Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan 411105, China.
J Org Chem. 2017 Mar 17;82(6):2935-2942. doi: 10.1021/acs.joc.6b02892. Epub 2017 Feb 24.
An efficient one-pot two-step indole-to-carbazole strategy has been developed. This transition metal-free methodology uses oxygen as the sole oxidant and starts from cheap and readily available indoles, ketones, and alkenes. The present protocol efficiently enables the assembly of a diverse array of substituted carbazole products with good regioselectivity and broad tolerance of functional groups.
一种高效的一锅两步吲哚到咔唑的策略已经被开发出来。这种无过渡金属的方法使用氧气作为唯一的氧化剂，起始原料为廉价易得的吲哚、酮和烯烃。该方法能够高效地构建各种取代的咔唑产物，具有良好的区域选择性和广泛的官能团耐受性。
