Fujisao Elaine Keiko, Cristaldo Nathalia Raquel, da Silva Braga Aline Marques, Cunha Paulina Rodrigues, Yamashita Seizo, Betting Luiz Eduardo
Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
Departamento de Doenças Tropicais e Diagnósticos por Imagem, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP) , Botucatu , Brazil.
Front Neurol. 2017 Feb 6;8:24. doi: 10.3389/fneur.2017.00024. eCollection 2017.
A 59-year-old man was admitted with respiratory tract infection, compromised conscience and generalized tonic-clonic seizures. His medical history included schizophrenia diagnosis, for which he had been being treated since he was 27 years old. EEG disclosed non-convulsive status epilepticus. A magnetic resonance image (MRI) acquired 3 days later showed increased left hippocampal volume with hyperintensity on T2-weighted and FLAIR sequences. After being treated with antibiotics and antiepileptic medications, the patient's condition improved. A follow-up MRI showed reduction of the left hippocampus. The relationship between epilepsy and schizophrenia is not yet clear. This case illustrates this interaction. Hippocampal atrophy may have been caused by environmental aggression in the present patient with schizophrenia, perhaps in association with a predisposing genotype.
一名59岁男性因呼吸道感染、意识障碍和全身性强直阵挛发作入院。他的病史包括自27岁起就被诊断为精神分裂症并接受治疗。脑电图显示非惊厥性癫痫持续状态。3天后进行的磁共振成像（MRI）显示左侧海马体积增大，T2加权和液体衰减反转恢复（FLAIR）序列上呈高信号。在接受抗生素和抗癫痫药物治疗后，患者病情好转。随访MRI显示左侧海马体积减小。癫痫与精神分裂症之间的关系尚不清楚。本病例说明了这种相互作用。在该精神分裂症患者中，海马萎缩可能是由环境侵害引起的，或许与易感基因型有关。
