Menaker Nathan, Halligan Katharine, Shur Natasha, Paige John, Hickling Matthew, Nepo Anne, Weintraub Lauren
Divisions of *Pediatric Hematology/Oncology †Genetics, Albany Medical Center ‡Department of Emergency Medicine, St Peter's Hospital, Albany, NY.
J Pediatr Hematol Oncol. 2017 Apr;39(3):217-222. doi: 10.1097/MPH.0000000000000786.
This case report details a unique case of acute, reversible liver failure in a 12-year-old male with sickle cell anemia on chronic transfusion protocol and deferasirox chelation. There is substantial literature documenting deferasirox-induced renal injury, including Fanconi syndrome, but less documentation of hepatic toxicity and few reports of hepatic failure. The case highlights the importance of close monitoring of ferritin, bilirubin, and transaminases for patients on deferasirox.
本病例报告详细介绍了一名12岁患有镰状细胞贫血的男性患者的独特急性可逆性肝衰竭病例，该患者接受慢性输血方案及地拉罗司螯合治疗。有大量文献记录了地拉罗司引起的肾损伤，包括范科尼综合征，但关于肝毒性的文献较少，肝衰竭的报告也很少。该病例强调了对接受地拉罗司治疗的患者密切监测铁蛋白、胆红素和转氨酶的重要性。
