Fredriksson Irma, Fredholm Hanna
Karolinska Universitetssjukhuset Brost- och Endokrinkirurgiska Kliniken - Stockholm, Sweden Karolinska Universitetssjukhuset Brost- och Endokrinkirurgiska Kliniken - Stockholm, Sweden.
Lakartidningen. 2017 Feb 14;114:EEIT.
Breast cancer in young women is uncommon, but the second most frequent cause of death in this age group. Young women with breast cancer have a worse prognosis than middle-aged women, with a higher risk of local recurrence, distant disease and breast cancer death. This can partly be explained by diagnosis at a later stage, and a higher proportion of tumors with unfavourable characteristics. However, in women with tumors of the luminal B subtype, low age remained an independent prognostic factor of DDFS and LRFS after correction for stage, tumor characteristics and treatment. Treatment of young women with breast cancer requires special skills to deal with the age group-specific questions concerning heredity, sexuality, fertility, and pregnancy.
年轻女性患乳腺癌并不常见，但却是该年龄组第二常见的死亡原因。患有乳腺癌的年轻女性预后比中年女性更差，局部复发、远处转移和乳腺癌死亡风险更高。这部分可以通过较晚阶段的诊断以及具有不良特征的肿瘤比例较高来解释。然而，对于管腔B亚型肿瘤的女性，校正分期、肿瘤特征和治疗后，低年龄仍然是无病生存期（DDFS）和局部复发无进展生存期（LRFS）的独立预后因素。治疗年轻乳腺癌女性需要特殊技能，以处理与遗传、性、生育和妊娠等特定年龄组相关的问题。
